Hepatosight®

Product Description | hiPSC-Derived liver cells

NUOXINTE Biotechnology is committed to providing high-quality hepatosight derived from human induced stem cells (hiPSC) using optimized unique differentiation techniques®。 Hepatotoxicity is a common problem in new drug development and one of the main reasons for the failure of new drug development. At present, it mainly relies on primary liver cells lacking reproducibility or immortalized cells with abnormal phenotypes. Due to the inability of both to meet the requirements of in vitro studies, hiPSC derived liver cells Hepatosight® Can fill this gap. Hepatosight® is a high-purity and functionally active liver cell that can detect various metabolic applications such as albumin secretion, glycogen production, and CYP activity, ensuring reliable data for researchers. Hepatosight® is the perfect choice for testing tissue-specific studies, toxicity screening, efficacy testing, and drug discovery formulas. The Certificate of Analysis (CoA) contains the accurate results we have obtained, and our technical support team will continue to communicate with you to help you have a better experience in the laboratory.

Item No.ProductsSpecifications
H-001

Hepatosight®, small

hiPSC-Derived liver cells

≥5 × 10⁶ cells

H-002

Hepatosight®, large

hiPSC-Derived liver cells

≥10 × 10⁶ cells

HMS-001

Hepatosight® Maintenance Basic Medium (HM-001, 70 ml)

Hepatosight® Maintenance Supplement (HS-001, 0.7 ml)

About 70 ml

HMS-002

Hepatosight® Maintenance Basic Medium (HM-002, 120 ml)

Hepatosight® Maintenance Supplement (HS-002, 1.2 ml)

About 120 ml

Product Introduction | hiPSC-Derived liver cells

Morphology

Hepatosight® rapidly recovers after thawing, forming a polygonal cell monolayer. 12 well culture dish images of Hepatosight® at 1, 3, 5, and 8 days post resuscitation (magnification 100x). The board density of Hepatosight® is 250000 cells per square meter. Please refer to Hepatosight for detailed instructions® Product manual.

Features

  • ALB

    HNF4A

    DAPI

  • A1AT

    DAPI

  • ASGPR1

    DAPI

Hepatosight® expresses liver cell specific genes (ALB, HNF4A, A1AT, ASGPR1),  And it has normal structural characteristics.

Compared with HepG2 liver cells, Hepatosight® shows higher accuracy in liver toxicity screening and is closer to primary liver cells. Hepatosight® expresses over 97% ALB positivity.